Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Mutations in synaptic NMDA receptors (NMDARs) are associated with epilepsy and neurodevelopmental disorders. The effects of several such mutations have been investigated in recombinantly-expressed NMDARs under conditions of steady-state activation. Such experiments provide only limited insight into...

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Bibliographic Details
Main Authors: Xiumin Chen, Angelo Keramidas, Robert J. Harvey, Joseph W. Lynch
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Mutation
NMDA receptors
Glutamatergic
Excitatory postsynaptic current
Memantine
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030125X

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http://www.sciencedirect.com/science/article/pii/S096999612030125X

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