Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ

The catalytic activity of dioxygenase AsqJ is strictly relying on the methylation of quinolone substrates. Here, the authors apply molecular simulations, X-ray crystallography and in vitro biochemical studies to the engineering of dioxygenase AsqJ with improved catalytic activity for modified non-me...

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Bibliographic Details
Main Authors: Sophie L. Mader, Alois Bräuer, Michael Groll, Ville R. I. Kaila
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03442-2