Hippo-YAP/MCP-1 mediated tubular maladaptive repair promote inflammation in renal failed recovery after ischemic AKI

Abstract Acute kidney injury (AKI) is associated with significant morbidity and its chronic inflammation contributes to subsequent chronic kidney disease (CKD) development. Yes-associated protein (YAP), the major transcriptional coactivator of the Hippo pathway, has been shown associated with chroni...

Full description

Bibliographic Details
Main Authors: Zhihuang Zheng, Chuanlei Li, Guangze Shao, Jinqing Li, Kexin Xu, Zhonghua Zhao, Zhigang Zhang, Jun Liu, Huijuan Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04041-8