The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease

The Length of SNCA Rep1 Microsatellite May Influence Cognitive Evolution in Parkinson’s Disease

BackgroundAlpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson’s disease (PD). A previous study showed that a variant of the alpha-synuclein gene (SNCA), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary...

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Bibliographic Details
Main Authors: Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D’Alfonso, Corrado Magnani, Giacomo P. Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neurology
Subjects:
dementia
hallucinations
genetic markers
disease progression
Parkinson’s disease
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00213/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00213/full

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