Type 1 Interferon Gene Signature Promotes RBC Alloimmunization in a Lupus Mouse Model

Type 1 Interferon Gene Signature Promotes RBC Alloimmunization in a Lupus Mouse Model

Red blood cell (RBC) transfusion exposes recipients to hundreds of unmatched minor RBC antigens. This exposure can lead to production of alloantibodies that promote clinically significant hemolytic events. Multiple studies have reported an increased frequency of RBC alloimmunization in patients with...

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Bibliographic Details
Main Authors: June Young Lee, Emaan Madany, Najwa El Kadi, Sumaarg Pandya, Kessandra Ng, Michifumi Yamashita, Caroline A. Jefferies, David R. Gibb
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
RBC alloimmunization
type 1 interferons
lupus
transfusion
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.584254/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.584254/full

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