Intra-Familial Phenotypic Heterogeneity and Telomere Abnormality in von Hippel- Lindau Disease: Implications for Personalized Surveillance Plan and Pathogenesis of VHL-Associated Tumors

Intra-Familial Phenotypic Heterogeneity and Telomere Abnormality in von Hippel- Lindau Disease: Implications for Personalized Surveillance Plan and Pathogenesis of VHL-Associated Tumors

von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease an...

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Bibliographic Details
Main Authors: Jiangyi Wang, Xiang Peng, Cen Chen, Xianghui Ning, Shuanghe Peng, Teng Li, Shengjie Liu, Baoan Hong, Jingcheng Zhou, Kaifang Ma, Lin Cai, Kan Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
von Hippel-Lindau disease
phenotypic heterogeneity
genetic anticipation
birth order effect
telomere length
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00358/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00358/full

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