CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

Abstract Background Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-...

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Bibliographic Details
Main Authors: Xiangyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu, Mengjie Wang, Wei Lv, Rong Zhang, Juan Shi, Lihua Liu
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Cancer Cell International
Subjects:
CDK5
BIN1
c-MYC
NSCLC
Online Access:http://link.springer.com/article/10.1186/s12935-019-0952-5

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http://link.springer.com/article/10.1186/s12935-019-0952-5

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