Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Abstract The goal of cell culture process intensification is to increase volumetric productivity, generally by increasing viable cell density (VCD), cell specific productivity or production bioreactor utilization in manufacturing. In our previous study, process intensification in fed-batch productio...

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Bibliographic Details
Main Authors: Jianlin Xu, Matthew S. Rehmann, Mengmeng Xu, Shun Zheng, Charles Hill, Qin He, Michael C. Borys, Zheng Jian Li
Format: Article
Language:English
Published: SpringerOpen 2020-03-01
Series:Bioresources and Bioprocessing
Subjects:
Fed-batch platform
Process intensification
Monoclonal antibody manufacturing
Perfusion N-1
Chinese hamster ovary cells
Online Access:http://link.springer.com/article/10.1186/s40643-020-00304-y

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http://link.springer.com/article/10.1186/s40643-020-00304-y

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