Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages

Abstract Background Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment. Methods The effec...

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Bibliographic Details
Main Authors: Yong Li, Fengjun Cao, Mingxing Li, Pindong Li, Yuandong Yu, Longchao Xiang, Tao Xu, Jinhua Lei, Yun Yan Tai, Jianyong Zhu, Bingbing Yang, Yingpin Jiang, Xiufang Zhang, Long Duo, Ping Chen, Xiongjie Yu
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hydroxychloroquine
Lung cancer
Chemotherapy resistance
Lysosome
Acidification
Macrophage remodelling
Online Access:http://link.springer.com/article/10.1186/s13046-018-0938-5

Internet

http://link.springer.com/article/10.1186/s13046-018-0938-5

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