Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in cholesterol transport. Using a sensitive method...

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Bibliographic Details
Main Authors: Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
ldl cholesterol
lysosome
niemann pick c disease
ezetimibe
cholesterol transport
Online Access:https://elifesciences.org/articles/57089

Internet

https://elifesciences.org/articles/57089

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