Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in cholesterol transport. Using a sensitive method...
Main Authors: | Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/57089 |
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