Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Abstract Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases. High circulating levels of TMAO and its dietary precursor, choline, predict increased risk for de...

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Bibliographic Details
Main Authors: Wenchao Zhang, Aika Miikeda, Jonathan Zuckerman, Xun Jia, Sarada Charugundla, Zhiqiang Zhou, Karolina Elżbieta Kaczor-Urbanowicz, Clara Magyar, Fangfei Guo, Zeneng Wang, Matteo Pellegrini, Stanley L. Hazen, Susanne B. Nicholas, Aldons J. Lusis, Diana M. Shih
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80063-0

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https://doi.org/10.1038/s41598-020-80063-0

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