Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer

Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer

Defective DNA damage response (DDR) pathways are enabling characteristics of cancers that not only can be exploited to specifically target cancer cells but also can predict chemotherapy response. Defective Homologous Recombination Repair (HRR) function, e.g., due to BRCA1/2 loss, is a determinant of...

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Bibliographic Details
Main Authors: Sweta Sharma Saha, Lucy Gentles, Alice Bradbury, Dominik Brecht, Rebecca Robinson, Rachel O’Donnell, Nicola J. Curtin, Yvette Drew
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
DNA damage repair
chemotherapy
ovarian cancer
biomarker
Online Access:https://www.mdpi.com/2072-6694/13/6/1420

Internet

https://www.mdpi.com/2072-6694/13/6/1420

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