Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning

Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning

Membrane proteins are attractive targets for monoclonal antibody (mAb) discovery and development. Although several approved mAbs against membrane proteins have been isolated from phage antibody libraries, the process is challenging, as it requires the presentation of a correctly folded protein to sc...

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Bibliographic Details
Main Authors: Mohamed A. Alfaleh, Martina L. Jones, Christopher B. Howard, Stephen M. Mahler
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Antibodies
Subjects:
affinity selection
antibodies
cell markers
cell receptors
competitive elution
epitopes
panning
phage display
transfection
whole cell
Online Access:https://www.mdpi.com/2073-4468/6/3/10

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https://www.mdpi.com/2073-4468/6/3/10

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