Mitochondrial Regulation of the 26S Proteasome

Mitochondrial Regulation of the 26S Proteasome

Summary: The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs. Here, we demonstrate that mitochondrial dysfunction and concomitant metabolic reprogramming of the tricarboxylic acid (TCA) cycle reduce the assembly and...

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Bibliographic Details
Main Authors: Thomas Meul, Korbinian Berschneider, Sabine Schmitt, Christoph H. Mayr, Laura F. Mattner, Herbert B. Schiller, Ayse S. Yazgili, Xinyuan Wang, Christina Lukas, Camille Schlesser, Cornelia Prehn, Jerzy Adamski, Elisabeth Graf, Thomas Schwarzmayr, Fabiana Perocchi, Alexandra Kukat, Aleksandra Trifunovic, Laura Kremer, Holger Prokisch, Bastian Popper, Christine von Toerne, Stefanie M. Hauck, Hans Zischka, Silke Meiners
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
26S proteasome
mitochondria
respiratory complex I
aspartate
metabolic reprogramming
proteasome assembly factors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310445

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http://www.sciencedirect.com/science/article/pii/S2211124720310445

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