Trametinib therapy for children with neurofibromatosis type 1 and life‐threatening plexiform neurofibroma or treatment‐refractory low‐grade glioma

Trametinib therapy for children with neurofibromatosis type 1 and life‐threatening plexiform neurofibroma or treatment‐refractory low‐grade glioma

Abstract Purpose To describe a series of children with extensive PNF or treatment refractory PLGG treated on a compassionate basis with trametinib. Methods We report on six patients with NF‐1 treated with trametinib on a compassionate basis at British Columbia Children's Hospital since 2017. Da...

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Bibliographic Details
Main Authors: Rebecca Ronsley, Celine D. Hounjet, Sylvia Cheng, Shahrad Rod Rassekh, Walter J. Duncan, Christopher Dunham, Jane Gardiner, Arvindera Ghag, Jeffrey P. Ludemann, David Wensley, Wingfield Rehmus, Michael A. Sargent, Juliette Hukin
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Cancer Medicine
Subjects:
low‐grade glioma
neurofibromatosis
pediatric
plexiform neurofibroma
trametinib
Online Access:https://doi.org/10.1002/cam4.3910

Internet

https://doi.org/10.1002/cam4.3910

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