PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer

Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using...

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Bibliographic Details
Main Authors: Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301967

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http://www.sciencedirect.com/science/article/pii/S2211124718301967

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