High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch

Riboswitches are important model systems for the development of approaches to search for RNA-targeting therapeutics. A principal challenge in finding compounds that target riboswitches is that the effector ligand is typically almost completely encapsulated by the RNA, which severely limits the chemi...

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Bibliographic Details
Main Authors: Michal M. Matyjasik, Simone D. Hall, Robert T. Batey
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
RNA
Online Access:https://www.mdpi.com/1420-3049/25/10/2295