An observational study identifying highly tuberculosis-exposed, HIV-1-positive but persistently TB, tuberculin and IGRA negative persons with M. tuberculosis specific antibodies in Cape Town, South Africa

An observational study identifying highly tuberculosis-exposed, HIV-1-positive but persistently TB, tuberculin and IGRA negative persons with M. tuberculosis specific antibodies in Cape Town, South Africa

Background: Mycobacterium tuberculosis (Mtb) infection is inferred from positive results of T-cell immune conversion assays measuring Mtb-specific interferon gamma production or tuberculin skin test (TST) reactivity. Certain exposed individuals do not display T-cell immune conversion in these assays...

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Bibliographic Details
Main Authors: Elouise E. Kroon, Craig J. Kinnear, Marianna Orlova, Stephanie Fischinger, Sally Shin, Sihaam Boolay, Gerhard Walzl, Ashley Jacobs, Robert J. Wilkinson, Galit Alter, Erwin Schurr, Eileen G. Hoal, Marlo Möller
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:EBioMedicine
Subjects:
Resister
Early clearance
Interferon gamma release assay
Tuberculin skin test
Antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420304291

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http://www.sciencedirect.com/science/article/pii/S2352396420304291

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