Pre-Senescence Induction in Hepatoma Cells Favors Hepatitis C Virus Replication and Can Be Used in Exploring Antiviral Potential of Histone Deacetylase Inhibitors

Pre-Senescence Induction in Hepatoma Cells Favors Hepatitis C Virus Replication and Can Be Used in Exploring Antiviral Potential of Histone Deacetylase Inhibitors

Recent evidence suggests that fibrotic liver injury in patients with chronic hepatitis C correlates with cellular senescence in damaged liver tissue. However, it is still unclear how senescence can affect replication of the hepatitis C virus (HCV). In this work, we report that an inhibitor of cyclin...

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Bibliographic Details
Main Authors: Alsu Z. Malikova, Anastasia S. Shcherbakova, Konstantin A. Konduktorov, Anastasia S. Zemskaya, Alexandra A. Dalina, Vladimir I. Popenko, Olga G. Leonova, Alexei V. Morozov, Nikolay N. Kurochkin, Olga A. Smirnova, Sergey N. Kochetkov, Maxim V. Kozlov
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus
TGF-β1
palbociclib
pre-senescence
DAAs
HTAs
Online Access:https://www.mdpi.com/1422-0067/22/9/4559

Internet

https://www.mdpi.com/1422-0067/22/9/4559

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