A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

The 39- to 42-residue amyloid β (Aβ) peptide is deposited in extracellular fibrillar plaques in the brain of patients suffering from Alzheimer's Disease (AD). Vaccination with these peptides seems to be a promising approach to reduce the plaque load but results in a dominant antibody response d...

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Bibliographic Details
Main Authors: Peter Hoogerhout, Willem Kamphuis, Humphrey F Brugghe, Jacqueline A Sluijs, Hans A M Timmermans, Janny Westdijk, Gijsbert Zomer, Claire J P Boog, Elly M Hol, Germie P J M van den Dobbelsteen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3079747?pdf=render

Internet

http://europepmc.org/articles/PMC3079747?pdf=render

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