β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Summary: β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called “trained immunity,” resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exposure confers protection against pulmonary Mycobacteri...

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Bibliographic Details
Main Authors: Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
trained immunity
β-glucan
tuberculosis
Mycobacterium tuberculosis
epigenetics
monocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305878

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720305878

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