Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus

Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus

Chronic intermittent hypoxia (CIH) is an underlying component of obstructive sleep apnoea and has been shown to have deleterious and damaging effects on central neurons and to impair synaptic plasticity in the CA1 region of the rat hippocampus. CIH has previously been shown to impair synaptic plasti...

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Bibliographic Details
Main Authors: Audrey M. Wall, Alan E. Corcoran, Ken D. O'Halloran, John J. O'Connor
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Chronic intermittent hypoxia (CIH)
Long term potentiation (LTP)
Cornu ammons 1 (CA1)
Dentate gyrus (dentate gyrus)
Dimethyloxaloylglycine (DMOG)
Prolyl hydroxylase domain (PHD)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002489

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http://www.sciencedirect.com/science/article/pii/S0969996113002489

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