Total Synthesis of Flocoumafen via Knoevenagel Condensation and Intramolecular Ring Cyclization: General Access to Natural Products

Total Synthesis of Flocoumafen via Knoevenagel Condensation and Intramolecular Ring Cyclization: General Access to Natural Products

The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction...

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Bibliographic Details
Main Authors: Mankil Jung, Oee-Sook Park, Jeremy Ricci, Dongguk Min, Yongnam Lee, Jae-Chul Jung, Eunyoung Lim
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:Molecules
Subjects:
flocoumafen
Knoevenagel condensation
tetralone
2D NMR analysis
computer simulation
Online Access:http://www.mdpi.com/1420-3049/17/2/2091/

Internet

http://www.mdpi.com/1420-3049/17/2/2091/

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