Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study

Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study

Abstract Objective Associations between rheumatoid arthritis (RA) and effect of treatment at the tissue levels are poorly understood. We investigated the scope of released extracellular matrix (ECM) metabolites as a consequence of tissue remodelling in patients treated with methotrexate (MTX) and to...

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Bibliographic Details
Main Authors: Patryk J. Drobinski, Anne C. Bay-Jensen, Morten A. Karsdal, Samra Sardar, Anne S. Siebuhr
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Arthritis Research & Therapy
Subjects:
Tocilizumab (TCZ)
Methotrexate (MTX)
Rheumatoid arthritis (RA)
Biomarkers
Tissue remodelling
Extracellular matrix (ECM)
Online Access:https://doi.org/10.1186/s13075-020-02378-7

Internet

https://doi.org/10.1186/s13075-020-02378-7

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