The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro

The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro

Abstract Background HSPB5 is an ATP-independent molecular chaperone that is induced by heat shock or other proteotoxic stresses. HSPB5 is cytoprotective against stress both intracellularly and extracellularly. It acts as a potential therapeutic candidate in ischemia-reperfusion and neurodegenerative...

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Main Authors: Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He, Yanzhong Hu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Biotechnology
Subjects:
HSPB5
Affinity purification
Chaperone activity
polyQ
Apoptosis
Online Access:https://doi.org/10.1186/s12896-021-00700-y

Internet

https://doi.org/10.1186/s12896-021-00700-y

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