The resistance of swine blood clots to alteplase-induced thrombolysis in vitro is concentration-dependent

Background: Swine have been used as a large animal translational research model to investigate the effectiveness of fibrinolytic agents. However, swine thrombi have different characteristics than human thrombi, which may confer more resistance to fibrinolysis. Methods: In this study, we performed an...

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Bibliographic Details
Main Authors: Evandro M. Neto-Neves, Daren M. Beam, Jeffrey A. Kline
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Thrombosis Update
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666572721000043