Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge.

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge.

Current hemagglutinin (HA)-based seasonal influenza vaccines induce vaccine strain-specific neutralizing antibodies that usually fail to provide protection against mismatched circulating viruses. Inclusion in the vaccine of highly conserved internal proteins such as the nucleoprotein (NP) and the ma...

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Bibliographic Details
Main Authors: Diletta Magini, Cinzia Giovani, Simona Mangiavacchi, Silvia Maccari, Raffaella Cecchi, Jeffrey B Ulmer, Ennio De Gregorio, Andrew J Geall, Michela Brazzoli, Sylvie Bertholet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4985159?pdf=render

Internet

http://europepmc.org/articles/PMC4985159?pdf=render

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