Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse

Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse

Conjugated linoleic acids (CLA) are a class of positional, geometric, conjugated dienoic isomers of linoleic acid (LA). Dietary CLA supplementation results in a dramatic decrease in body fat mass in mice, but also causes considerable liver steatosis. However, little is known of the molecular mechani...

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Bibliographic Details
Main Authors: Lionel Clément, Hélène Poirier, Isabelle Niot, Virginie Bocher, Michèle Guerre-Millo, Stéphane Krief, Bart Staels, Philippe Besnard
Format: Article
Language:English
Published: Elsevier 2002-09-01
Series:Journal of Lipid Research
Subjects:
conjugated linoleic acid
peroxisome proliferator-activated receptors
liver-X-receptors
sterol responsive element-binding proteins
hyperinsulinism
liver steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328030

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http://www.sciencedirect.com/science/article/pii/S0022227520328030

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