The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis

The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis

Liraglutide has been demonstrated to alleviate hepatic steatosis in clinical practice, but the underlying mechanism remains unclear. Our previous study indicated that the HIF-2α/PPARα pathway was involved in hepatic lipid accumulation induced by hypoxia.We aimed to investigate whether liraglutide co...

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Bibliographic Details
Main Authors: Hou Wang, Lingling Wang, Yun Li, Shunkui Luo, Jianfang Ye, Zhanjin Lu, Xiaobin Li, Hongyun Lu
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hypoxia
Hypoxia-inducible factor 2α
Peroxisome proliferator-activated receptor α
Lipid synthesis
Fatty acid β-oxidation
Metabolic associated fatty liver disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221005606

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http://www.sciencedirect.com/science/article/pii/S0753332221005606

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