In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Abstract Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdR...

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Bibliographic Details
Main Authors: Salvatore Ferla, Natalie E. Netzler, Sebastiano Ferla, Sofia Veronese, Daniel Enosi Tuipulotu, Salvatore Guccione, Andrea Brancale, Peter A. White, Marcella Bassetto
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-22303-y

Internet

https://doi.org/10.1038/s41598-018-22303-y

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