Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases

Background: Dendritic cells (DCs), which are the most powerful antigen-presenting cells, activate innate and adaptive immune responses. Wilms' tumor 1 (WT1) is a tumor-associated antigen that is frequently expressed in many human cancers including gliomas and is therefore a potential target of...

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Main Authors: Keiichi Sakai, MD, PhD, Shigetaka Shimodaira, MD, PhD, Shinya Maejima, MD, PhD, Kenji Sano, MD, PhD, Yumiko Higuchi, PhD, Terutsugu Koya, MS, Haruo Sugiyama, MD, PhD, Kazuhiro Hongo, MD, PhD
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Interdisciplinary Neurosurgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2214751916300561