Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

Silent information regulator 2 (Sir2), an NAD+-dependent protein deacetylase, has been proposed to be a longevity factor that plays important roles in dietary restriction (DR)-mediated lifespan extension. In this study, we show that the Sir2's role for DR-mediated lifespan extension depends on...

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Bibliographic Details
Main Authors: Woo Kyu Kang, Yeong Hyeock Kim, Hyun Ah Kang, Ki-Sun Kwon, Jeong-Yoon Kim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
Sir2
lifespan extension
dietary restriction
cAMP-PKA
CK2
phosphorylation
Online Access:https://elifesciences.org/articles/09709

Internet

https://elifesciences.org/articles/09709

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