Modeling PTEN overexpression-induced microcephaly in human brain organoids

Modeling PTEN overexpression-induced microcephaly in human brain organoids

Abstract The phosphatase and tensin homolog (PTEN) protein, encoded by the PTEN gene on chromosome 10, is a negative regulator of the phosphoinositide 3-kinase (PI3K) signaling pathway. Loss of PTEN has been linked to an array of human diseases, including neurodevelopmental disorders such as macroce...

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Bibliographic Details
Main Authors: Navroop Dhaliwal, Wendy W.Y. Choi, Julien Muffat, Yun Li
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Brain
Subjects:
PTEN
AKT
Brain organoids
Human pluripotent stem cells
Neural precursors
Microcephaly
Online Access:https://doi.org/10.1186/s13041-021-00841-3

Internet

https://doi.org/10.1186/s13041-021-00841-3

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