Dimethylfumarate Inhibits Colorectal Carcinoma Cell Proliferation: Evidence for Cell Cycle Arrest, Apoptosis and Autophagy

Dimethylfumarate Inhibits Colorectal Carcinoma Cell Proliferation: Evidence for Cell Cycle Arrest, Apoptosis and Autophagy

Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action....

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Bibliographic Details
Main Authors: Irina Kaluzki, Tsige Hailemariam-Jahn, Monika Doll, Roland Kaufmann, Panagiotis Balermpas, Nadja Zöller, Stefan Kippenberger, Markus Meissner
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
dimethylfumarate
colorectal carcinoma
p21
cell cycle arrest
cyclin d1
p62
lc3 i/ii
caspase-8
autophagy
Online Access:https://www.mdpi.com/2073-4409/8/11/1329

Internet

https://www.mdpi.com/2073-4409/8/11/1329

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