Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies

Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies

Abstract Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and...

Full description

Bibliographic Details
Main Authors: Dharmender Rathee, Viney Lather, Ajmer Singh Grewal, Harish Dureja
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Chemistry Central Journal
Subjects:
Targeting
MMP-2
MMP-9
Diazepine
Cinnamic acid
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s13065-018-0411-8

Internet

http://link.springer.com/article/10.1186/s13065-018-0411-8

Similar Items