Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies
Abstract Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-04-01
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Series: | Chemistry Central Journal |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13065-018-0411-8 |