Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis

Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown etiology, affects motor neurons leading to atrophy of skeletal muscles, paralysis and death. There is evidence for the accumulation of neurofilaments (NF) in motor neurons of the spinal cord in ALS cases. NF are major struct...

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Bibliographic Details
Main Authors: D.M.F. Mendonça, L. Chimelli, A.M.B. Martinez
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2005-06-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Amyotrophic lateral sclerosis
Spheroids
Neurofilament proteins
Immunohistochemistry
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600015

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