Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model.

Characterization of post-edited cells modified in the TFAM gene by CRISPR/Cas9 technology in the bovine model.

Gene editing in large animal models for future applications in translational medicine and food production must be deeply investigated for an increase of knowledge. The mitochondrial transcription factor A (TFAM) is a member of the HMGB subfamily that binds to mtDNA promoters. This gene maintains mtD...

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Bibliographic Details
Main Authors: Vanessa Cristina de Oliveira, Clésio Gomes Mariano Junior, José Ernesto Belizário, José Eduardo Krieger, Fabiana Fernandes Bressan, Kelly Cristine Santos Roballo, Paulo Fantinato-Neto, Flávio Vieira Meirelles, Marcos Roberto Chiaratti, Jean-Paul Concordet, Carlos Eduardo Ambrósio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235856

Internet

https://doi.org/10.1371/journal.pone.0235856

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