Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice

Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice

In low density lipoprotein receptor (LDLR)-deficient mice, overexpression of human plasma phospholipid transfer protein (PLTP) results in increased atherosclerosis. PLTP strongly decreases HDL levels and might alter the antiatherogenic properties of HDL particles. To study the potential interaction...

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Bibliographic Details
Main Authors: Matthijs Moerland, Hannelore Samyn, Teus van Gent, Matti Jauhiainen, Jari Metso, Rien van Haperen, Frank Grosveld, Arie van Tol, Rini de Crom
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
phospholipid transfer protein
apolipoprotein A-I
cholesterol
high density lipoprotein
low density lipoprotein
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042913X

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http://www.sciencedirect.com/science/article/pii/S002222752042913X

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