A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer’s Disease

A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer’s Disease

Alzheimer’s disease (AD), a progressive neurodegenerative disease, is characterized by the accumulation of senile plaques, neurofibrillary tangles, and loss of synapses and neurons in the brain. The pathophysiological process of AD begins with a long asymptomatic phase, which provides a potential op...

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Bibliographic Details
Main Authors: Xiaofang Zhong, Jingxin Wang, Cynthia Carlsson, Ozioma Okonkwo, Henrik Zetterberg, Lingjun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cerebrospinal fluid
Alzheimer’s disease
biomarker
label-free quantitation
targeted quantitative proteomics
isotopic labeling for quantitation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00483/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00483/full

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