EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality

EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality

Prostate cancer is the second leading cause of cancer-related death in men. Early prostate cancer has a high 5-year survival rate. However, the five-year survival rate is low in progressive prostate cancer, which manifests as bone metastasis. The EGF receptor overexpression increases during disease...

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Bibliographic Details
Main Authors: Tingting Chen, Jie Xu, Weihua Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
prostate cancer
EGFR
FoxO3a
LXR-α
proliferation
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.01688/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.01688/full

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