Novel Cytotoxic Oxopyridoindolizines: iso-Propyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC)

Novel Cytotoxic Oxopyridoindolizines: iso-Propyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC)

A series of eight new alkyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC), analogues of camptothecin (CPT), were prepared in a one-pot reaction of 2,2'-bipyridine-3,3'-dicarboxylic acid (BPA) with a mixture of thionyl chloride/chlorine, followed by...

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Bibliographic Details
Main Authors: Taibi Ben-Hadda, Assou Zahidi, Najat Sam, Mostafa Mimouni, Najib Ben Larbi, Maria Daoudi, Michael Waring, Ann T. Kotchevar, Franco Zunino
Format: Article
Language:English
Published: MDPI AG 2002-08-01
Series:Molecules
Subjects:
Oxopyridopyndolizine carboxylate (OPIC)
Cycloacylation
Camptothecin
Cancer
Chlorination
N-ligands
Online Access:http://www.mdpi.com/1420-3049/7/8/628/

Internet

http://www.mdpi.com/1420-3049/7/8/628/

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