Effect of mutations of N- and C-terminal charged residues on the activity of LCAT

Effect of mutations of N- and C-terminal charged residues on the activity of LCAT

On the basis of structural homology calculations, we previously showed that lecithin:cholesterol acyltransferase (LCAT), like lipases, belongs to the α/β hydrolase fold family. As there is higher sequence conservation in the N-terminal region of LCAT, we investigated the contribution of the N- and C...

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Bibliographic Details
Main Authors: Frank Peelman, Berlinda Vanloo, Jean-Luc Verschelde, Christine Labeur, Hans Caster, Josée Taveirne, Annick Verhee, Nicolas Duverger, Joël Vandekerckhove, Jan Tavernier, Maryvonne Rosseneu
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Journal of Lipid Research
Subjects:
enzyme
lipase
structure
ionic interactions
phospholipid
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520303655

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http://www.sciencedirect.com/science/article/pii/S0022227520303655

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