Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.

Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known,...

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Bibliographic Details
Main Authors: Valerie J Klema, Mengyi Ye, Aditya Hindupur, Tadahisa Teramoto, Keerthi Gottipati, Radhakrishnan Padmanabhan, Kyung H Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4760774?pdf=render

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http://europepmc.org/articles/PMC4760774?pdf=render

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