Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.

Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8(+) T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However,...

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Bibliographic Details
Main Authors: Alireza Saeidi, Vicky L Tien Tien, Rami Al-Batran, Haider A Al-Darraji, Hong Y Tan, Yean K Yong, Sasheela Ponnampalavanar, Muttiah Barathan, Devi V Rukumani, Abdul W Ansari, Vijayakumar Velu, Adeeba Kamarulzaman, Marie Larsson, Esaki M Shankar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4403924?pdf=render

Internet

http://europepmc.org/articles/PMC4403924?pdf=render

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