Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8(+) T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However,...
Main Authors: | Alireza Saeidi, Vicky L Tien Tien, Rami Al-Batran, Haider A Al-Darraji, Hong Y Tan, Yean K Yong, Sasheela Ponnampalavanar, Muttiah Barathan, Devi V Rukumani, Abdul W Ansari, Vijayakumar Velu, Adeeba Kamarulzaman, Marie Larsson, Esaki M Shankar |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4403924?pdf=render |
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