Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

Abstract Background Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer’s disease (AD) pathophysiologic continuum constituting what has been established as “AD signature”. To what extent MRI can detect amyloid-related cerebral changes from structural M...

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Bibliographic Details
Main Authors: Paula M. Petrone, Adrià Casamitjana, Carles Falcon, Miquel Artigues, Grégory Operto, Raffaele Cacciaglia, José Luis Molinuevo, Verónica Vilaplana, Juan Domingo Gispert, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Preclinical AD signature
Jacobian determinant
MRI
Machine learning
Longitudinal voxel-wise analysis
Online Access:http://link.springer.com/article/10.1186/s13195-019-0526-8

Internet

http://link.springer.com/article/10.1186/s13195-019-0526-8

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