Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production

Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production

The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, the prevention of AKI in diabetic nephropathy is feasible and of value. As we detected highly activation of TGF-β/Smad3 signaling in both human biopsy an...

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Bibliographic Details
Main Authors: Jia-Nan Wang, Qin Yang, Chen Yang, Yu-Ting Cai, Tian Xing, Li Gao, Fang Wang, Xin Chen, Xue-Qi Liu, Xiao-Yan He, Biao Wei, Ling Jiang, Chao Li, Juan Jin, Jia-Gen Wen, Tao-Tao Ma, Hai-Yong Chen, Jun Li, Xiao-Ming Meng
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Smad
TGF-β
Diabetic nephropathy
AKI
Inflammation
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719314946

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http://www.sciencedirect.com/science/article/pii/S2213231719314946

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