Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial reactivity. Here we show that the genetic deletion of mGlu3 receptors amplifies ischemic brain damage and associated neuroinflam...

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Bibliographic Details
Main Authors: Federica Mastroiacovo, Manuela Zinni, Giada Mascio, Valeria Bruno, Giuseppe Battaglia, Julien Pansiot, Tiziana Imbriglio, Jerome Mairesse, Olivier Baud, Ferdinando Nicoletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neurology
Subjects:
focal ischemia
knockout mice
neuroinflammation
pro-inflammatory genes
mGlu3 receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.668877/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.668877/full

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