Differentiation of Human Malignant Melanoma Cells that Escape Apoptosis After Treatment with 9-Nitrocamptothecin In Vitro

After in-vitro exposure to 0.05 μmol/L 9-nitrocamptothecin (9NC) for periods of time longer than 5 days, 65% to 80% of the human malignant melanoma SB1 B cells die by apoptosis, whereas the remaining cells are arrested at the G2-phase of the cell cycle. Upon discontinuation of exposure to 9NC the G...

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Bibliographic Details
Main Authors: Panayotis Pantazis, Devasis Chatterjee, Zhiyong Han, James Wyche
Format: Article
Language:English
Published: Elsevier 1999-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800438